Haemostasis

4 important forces:

1. Clot formation
2. Control of clot formation
3. Clot breakdown (fibrinolysis)
4. Control of clot breakdown

 

Other notes

Haemoglobin

[WG21:p547]

Also facilitates the action of AT3

Also a co-factor for lipoprotein lipase

Protamine and heparin

Protamine forms irreversible complex with heparin
--> Neutralise heparin

Deficiency of coagulation

Haemophilia A = Factor 8 deficient
* aka classic haemophilia

Haemophilia B = Factor 9 deficient
* aka Christmas disease

Haemophilia A and B are sex-linked