Characterised by positive feedback
Decreased perfusion may lead to increase anaerobic glycolysis, resulting in lactic acidosis
Resulting in:
--> Aggravate fall in BP
Depression of cardiovascular centres in the brainstem
--> Reduced sympathetic tone
--> Drop in BP
--> Further bleeding and drop in BP
Endotoxins from normal bacteria flora in intestines are normally inactivated by RES, mainly in the liver
When RES is depressed, endotoxins invade the circulation
--> Produce profound generalised vasodilation
Late complication of shock
Damage to capillary endothelial cells and alveolar epithelial cells
--> Release of cytokines
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Reviewed | 20050816 |