3. Physiology
        3.2. Cardiovascular
            3.2.5. Special circulations
                3.2.5.1. Cerebral blood flow
3.2.5.1.2. Intracranial pressure

Intracranial pressure

Monro-Kellie doctrine

 

However, when content increases (e.g. tumour growth)

--> Pressure increases slowly initially
* Because of translocation of CSF out of ventricles and into extracranial subarachnoid space

When this buffer is gone, then pressure increases very abruptly, as per Monro-Kelli doctrine.

 

Normal intracranial content

By volume:

Increase in cerebral blood flow

--> Increased intracranial blood volume 
+ Possible increase in CSF production

--> Increase in ICP

But, CSF translocation and increased CSF resorption limits rise in ICP.

NB:

At 112mmCSF, absorption and production of CSF are roughly equal
* [WG21:p617]

Techniques used to manipulate CBF and ICP

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