3. Physiology
        3.12. Renal
            3.12.7. Control of sodium and water excretion
3.12.7.2. Tubuloglomerular feedback

Tubuloglomerular feedback

[Ref:AV6:p110-112]

Macula densa cells

When NaCl content is high at macula densa cells

--> Increased NaCl uptake

--> Swelling of macula densa cells

--> Release of ATP

--> Stimulation of purinergic P2 receptors on mesangial cells and afferent arteriole smooth muscles

NB:

Effect of increased NaCl content

Contraction of mesangial cells
--> Reduction in effective filtration area
--> Decreases GFR

Contraction of afferent arteriole
--> Decreases GFR and RBF

Thus,

Other notes

NaCl content at macula densa also affect renin release

Thus,

Increased NaCl content at macula densa leads to

 



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