3. Physiology
        3.1. Acid and base
            3.1.3. Acid-base disturbances
3.1.3.1. Respiratory acidosis

Respiratory acidosis

[Ref: KB's online acid-base text]

PaCO2

PaCO2 is proportional to VCO2/VA

Thus,

PaCO2 increase when

Clinically, most cases are due to alveolar hypoventilation

Renal compensation in respiratory acidosis

Renal response (compensating by retention of bicarbonate) to a chronic respiratory acidosis is slower
* Takes 3 or 4 days to reach its maximum

Increased PaCO2
--> Increased intracellular pCO2 inside proximal tubular cells
--> Increased H+ secretion from PCT into lumen

End result

 

 

 

 



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