O2 is carried in blood in two forms:
Dissolved O2 follows Henry's Law
--> Amount dissolved is proportional to partial pressure
For each mmHg of PAO2, dissolved O2
= 0.003 mL of O2 per 100 mL of blood
= 0.03 mL of O2 per L of blood
O2 capacity
= Maximum amount of O2 that can be bound to Hb
= 1g of Hb can bind with 1.34mL of O2
= 1.34 x [Hb]
Normal O2 capacity
= 20.1mL of O2 per 100mL of blood
* Assuming [Hb] = 15g/dL
= mL/100mL
O2 capacity
* Does not include dissolved O2
* Does not depend on pO2
NB:
O2 saturation (%)
= O2 combined with Hb / O2 capacity
= (O2 content - dissolved O2)/O2 capacity
NB. West defined O2 capacity as maximum O2 bound to Hb, thus doesn't include dissolved O2.
NB. Nunn includes dissolved O2 in its definition of O2 capacity.
Functional saturation
= [OxyHb]/([OxyHb]+[DeoxyHb])
Fractional saturation
= [OxyHb]/[Total Hb]
NB:
O2 concentration (mL/dL)
= 1.34 x [Hb] x Sat + 0.003 x pO2
NB:
CaO2
= 1.34 x 15 x 0.975 + 0.003 x 100
= 19.5975 + 0.3
= 19.8975 mL O2 per 100mL blood
~ 20 mL/dL
CvO2
= 1.34 x 15 x 0.75 + 0.003 x 40
= 15.075 + 0.12
= 15.195 mL O2 per 100mL blood
~ 15 mL/dL