Atropine is not used as an anti-emetic agent due to its CVS effects
Atropine also delays gastric emptying (????class effect)
Glycopyrrolate has negligible intestinal absorption
Glycopyrrolate does NOT cross BBB
--> No central effect e.g. anti-emesis
Hyoscine | Atropine | Glycopyrrolate | |
Anti-emetic | ++ | + | 0 |
Sedation /
Amnesia |
+++ | + | 0 |
Anti-sialagogue | +++ | + | ++ |
Mydriasis | +++ | + | 0 |
Placental transfer | ++ | ++ | 0 |
Bronchodilation | + | ++ | ++ |
Tachycardia | + | +++ | ++ |