Cystic fibrosis is an inherited autosomal recessive condition.
Commonest cause of chronic suppurative lung disease in Caucasian children.
Caused by defect in a gene that encodes a protein CFTR (cystic fibrosis transmembrane conductance regulator) that serves as a chloride channel.
This defect leads to excessively thick and tenacious mucus, obstructive of the pancreatic duct with inspissated secretions, and elevated sweat chloride and sodium concentration.
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Created | 20040514 |