3. Physiology
        3.1. Acid and base
            3.1.2. Defence to acid-base disturbance
                3.1.2.1. Buffer
3.1.2.1.1. Contribution by buffering systems

Contribution by buffering systems

Contribution by buffer system

According to [WG21:p737-738]

Principle buffers in CSF and urine are bicarbonate and phosphate

According to KB's online acid-base text

Respiratory disorders predominately buffered in ICF
* 99% in respiratory acidosis buffered in ICF
* 97% in respiratory alkalosis

ECF is not not effective in buffering respiratory disorders because the main buffering system in ECF is bicarbonate

Metabolic acidosis

Contribution of buffering

Metabolic alkalosis

ICF = 32%
* Na-H exchange is responsible for most of the transfer of H+

 

 

Other notes

Isohydric principle

All buffer systems which participate in defence of acid-base changes are in equilibrium with each other. There is after all only one value for [H+] at any moment.

This is known as the Isohydric Principle

 



Table of contents  | Bibliography  | Index