Principle buffers in CSF and urine are bicarbonate and phosphate
Respiratory disorders predominately buffered in ICF
* 99% in respiratory acidosis buffered in ICF
* 97% in respiratory alkalosis
ECF is not not effective in buffering respiratory disorders because the main buffering system in ECF is bicarbonate
Contribution of buffering
ICF = 32%
* Na-H exchange is responsible for most of the transfer of H+
All buffer systems which participate in defence of acid-base changes are in equilibrium with each other. There is after all only one value for [H+] at any moment.
This is known as the Isohydric Principle