3. Physiology
        3.2. Cardiovascular
            3.2.4. Regulatory mechanisms
                3.2.4.2. Regulation of peripheral blood flow
                    3.2.4.2.1. Local control
3.2.4.2.1.1. Endothelium-related vasoactive substances

Endothelium-related vasoactive substances

Endothelium-related vasodilators

Prostacyclin

[BL8:p159, WG21:p600]

Relax vascular smooth muscles via increased cAMP

Formed in endothelium from arachidonic acid

Released by shear stress caused by pulsatile blood flow

Note:

Endothelium-derived relaxing factor (EDRF)

NO release from endothelium
--> Diffused into vascular smooth muscle
--> NO activates guanylyl cyclase
--> Increase cGMP
--> Decrease cytosolic free Ca2+
--> Relaxation

Production of NO

NB:

 

Endothelium-related vasoconstrictors

Endothelin



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