competitive inhibitor of ace
afterload reduction, myocardial remodeling in CCF
reduce SVR, decrease BP, no increase in HR
Adverse effect:
well absorbed - bioavailibility 65%
Enalopril
prodrug via hepatic metabolism
hydrolysed in liver and kidney to active metabolite
elimination half life - 4-8 hrs
duration of effect 20hrs
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GTN
Effects
Adverse effects:
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N-acetyl cysteine can be used to loosen secretion
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Verapamil and diltiazem acts on the inner gate of calcium channel
Nifedipine acts on the outer gate of calcium channel
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Magnesium, calcium role in antiarrhythmia
Magnesium -
Vasodilation
Used for ventricular arrhythmia
Blocks NMDA receptor
Inhibits release of Ach at NMJ (Calcium enhance release)
Inhibits release of NE and other neurotransmitters
Used in bone formation