Need to know porphyria, pseudocholinesterase,
Porphyria
- midazolam is safe
- propofol is safe
Esterase (Pseudocholinesterase, plasma cholinesterase, + others??)
Pseudocholinesterase
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Dantrolene also contains mannitol and sodium hydroxide
Mannitol is also present in vecuronium
Sodium hydroxide also present in propofol
Dantrolene
Hydantoin derivative
Demonstrated effective in pigs in 1975
Elimination halflife 9-12 hr
Exact mechanism of action unknown
Interacts with RYR1 to prevent Ca2+ release from SR
S/E:
C/I:
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