Nernst equation

Ek = RT/FZk ln{[Ko]/[Ki]}
= 61.5 log{[Ko]/[Ki]}

 

 

 

 

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[WG21:p34-35]

Regulation of Na-K ATPase activity

Stimulator

• Intracellular [Na+]
  * Normally not saturating
  * When intracellular [Na+] increase, ATPase increase
• cAMP
• DAG
• Thyroid hormone
  * By increasing number of pumps
• Aldosterone
• Insulin

Inhibitor

• Dopamine in kidney
  * Phosphorylating ATPase
  --> Inactivating it
  --> Natriuresis

[HH26:p428] Looking at figure 41-13, Mg2+ seems to be a cofactor in Na-K ATPase pump

(I think it is also mentioned in WG21, but can't find it)