3. Physiology
        3.3. Endocrinology
3.3.6. Erythropoietin

Erythropoietin

[Ref: WG21: 463-464; PK1:p307-308; KB2:p208]

Function

Increase RBC production
* Increase in circulating RBC appears 2-3 days later

Mechanism of action

1. Increasing RBC precursors by

2. Shorten the time between recruitment of precursor stem cells and release of reticulocytes

Receptor

Has tyrosine kinase activity

Belongs to cytokine superfamily

Metabolism

Source of erythropoietin

Others

Adult vs foetus/neonate

During foetal and neonatal life

Liver is

Subsequently,

NB:

Stimulation for release

Others

[WG21:p464]

[PK1:p308]

NB:

Recombinant erythropoietin

Epoetin alfa

Other notes



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