Occurs via
Variability in the intrinsic water permeability across nephron segments is mostly due to variabilities in:
i.e. increased urine flow due to abnormally high amount of any substance in the glomerular filtrate that is reabsorbed incompletely or not at all by proximal tubules.
e.g. glucose
Because of:
1. Presence of high amount of non-sodium solute
--> Its osmotic pressure impairs water reabsorption in proximal tubule
--> Amount of water remains high in the lumen
2. Tight junction in proximal tubule is leaky to sodium
--> Sodium transport is a gradient-limited system
Thus,
Increased water content
--> Luminal sodium concentration slightly lower than interstitial
--> Sodium diffuses back from interstitium into lumen through tight junction
Water is reabsorbed with sodium
Water reabsorption without significant sodium reabsorption
Both thick and thin ascending limbs are impermeable to water
Sodium reabsorption without water reabsorption
Fraction of sodium reabsorbed is greater than fraction of water reabsorbed
--> Dilution of the tubular content
Impermeable to water
Sodium reabsorption without water reabsorption
--> Further dilution of tubular content
Water permeability in CCD and MCD
--> Subject to control by ADH
Water reabsorption
* via apical aquaporin 2
* in principle cells