3.6.3. Plasma protein
Plasma proteins
[Ref: KB2:p188]
Major class of plasma proteins
- Albumin
- Globulin
- Fibrinogen
Globulin
- Alpha-1
- Alpha-2
- Beta
- Gamma
* Almost all gamma globulin class consists of immunoglobulins
Normal concentration
- Normal concentration of plasma proteins
= 50 to 80 g/L
- Albumin
= 45g/L
- Globulin
= 25 g/L
- Fibrinogen
= 3 g/L
NB:
- Immunoglobulin
= 10 to 15g of total globulins
* IgG = 76%
* IgA = 16%
* IgM = 7%
* IgE = very low
* [PK1:p258]
Functions of plasm proteins
- Oncotic pressure
- Transport/carrier function
- Acid-base balance
* Buffer
* CO2 transport
- Proteolytic systems
* Complement system
* Kinin system
* Coagulation system
* Fibrinolytic system
- Immune response
* esp antibodies, cytokines
- Enzyme activity
* e.g. pseudocholinesterase
- Metabolism
* Provides amino acids for tissues for anabolic or catabolic purpose
Albumin
- Is a major component of plasma protein
= 35-55g/L
- Net albumin synthesis
= 12 to 15 g/day
= 25% of daily protein synthesis by liver
- Is not a glycoprotein
* Almost the only plasma protein that is not a glycoprotein
- Intravascular half-life in circulation
= 20 days
- About 5% of albumin enters ISF from capillaries
* Returns to circulation via the lymphatic system
Distribution of albumin
- Intravascular = 40 to 50%
- Extravascular = 50 to 60%
Main functions of albumin
- Oncotic pressure
- Transport/carrier function
NB:
- Can also form carbamino compound with CO2
- But quantitatively Hb is much more important
Albumin can bind to
- Free fatty acid
- Bilirubin
- Calcium
- Some hormones
* e.g. cortisol, thyroxine
- Copper
- Drugs
* Mostly acidic drugs
* Basic drugs are mainly bound by alpha-1 acid glycoprotein
Structure
- 585 amino acid residues
- MW = 69000