IV induction agents
Propofol vs thiopentone
Others
Mode of actions - May be agent specific
Ligand gated
GABAa receptor
Glycine receptor
Serotonin 5HT receptors
Nicotinic acetylcholine receptors
Iontotropic receptors
GABA receptor
Inhibitory
Chloride channel --> Hyperpolarise cell
2 alpha, 2 beta, 1gmma
Great heterogenecity
Most anaesthetic agents act on GABAa except xenon, cyclopropane, N2O, ketamine
Barbiturates
Widespread effect
GABAa
No action on NMDA
Propofol, etomidate -- specific for GABAa
Ketamine acts on NMDA
Thiopentone vs propofol in general
Thiopentone vs propofol in TIVA
Remifentanil
Short HL depends on metabolism through easterase AND small initial Vd