2.6. Elderly

 

 

 

 

 

 

Elderly also more likely to have polypharmacy
--> Drug interaction more likely

Decreased CO
--> Slower delivery of drugs to effect-site
--> Slower onset of action

 

Smaller Vd
--> Greater plasma concentration

 

Receptor number, affinity

 

Loss of compensatory mechanisms

 

 

 

 

 



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