3. Physiology
        3.4. General physiology
            3.4.6. Electrolytes
                3.4.6.1. Distribution of ions
3.4.6.1.2. Sodium distribution

Sodium distribution

Extracellular vs intracellular

Extracellular (plasma) concentration
= 140 mmol/L

Intracellular concentration
= 10 mmol/L

Interstitial concentration
= 140 mmol/L

NB:

[KB2:p13]

Interstitial concentration of protein is lower than plasma concentration

According to Gibbs-Donnan equilibrium
--> Sodium concentration in ISF should be lower

In fact, this is the case
--> Sodium concentration in the plasma water (i.e. without proteins) is about 6 or 7 mmol/L higher than ISF
--> But overall concentration is roughly the same

Body sodium distribution

[KB2:p14]

Total body Na+
= 60mmol/kg

NB:

NB:

Also see Daily balance of sodium and water



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